Embryonic viability, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficient mouse model

BACKGROUND: Lipase Maturation Factor 1 (LMF1) is an ER-chaperone involved in the post-translational maturation and catalytic activation of vascular lipases including lipoprotein lipase (LPL), hepatic lipase (HL) and endothelial lipase (EL). Mutations in LMF1 are associated with lipase deficiency and...

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Bibliographic Details
Main Authors: Ehrhardt, Nicole, Bedoya, Candy, Péterfy, Miklós
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190935/
https://ncbi.nlm.nih.gov/pubmed/25302068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-7075-11-37
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