[Ca(2+)](i) oscillations in ASM: Relationship with persistent airflow obstruction in asthma

The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extra...

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Main Authors: Sweeney, David, Hollins, Fay, Gomez, Edith, Saunders, Ruth, Challiss, RA John, Brightling, Christopher E
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Scientific Letter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190647/
https://ncbi.nlm.nih.gov/pubmed/24850215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/resp.12318
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spelling pubmed-41906472014-10-20 [Ca(2+)](i) oscillations in ASM: Relationship with persistent airflow obstruction in asthma Sweeney, David Hollins, Fay Gomez, Edith Saunders, Ruth Challiss, RA John Brightling, Christopher E Respirology Scientific Letter The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation. BlackWell Publishing Ltd 2014-07 2014-05-22 /pmc/articles/PMC4190647/ /pubmed/24850215 http://dx.doi.org/10.1111/resp.12318 Text en © 2014 The Authors. Respirology published by Wiley Publishing Asia Pty Ltd on behalf of Asian Pacific Society of Respirology. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Scientific Letter
spellingShingle Scientific Letter
Sweeney, David
Hollins, Fay
Gomez, Edith
Saunders, Ruth
Challiss, RA John
Brightling, Christopher E
[Ca(2+)](i) oscillations in ASM: Relationship with persistent airflow obstruction in asthma
description The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation.
author Sweeney, David
Hollins, Fay
Gomez, Edith
Saunders, Ruth
Challiss, RA John
Brightling, Christopher E
author_facet Sweeney, David
Hollins, Fay
Gomez, Edith
Saunders, Ruth
Challiss, RA John
Brightling, Christopher E
author_sort Sweeney, David
title [Ca(2+)](i) oscillations in ASM: Relationship with persistent airflow obstruction in asthma
title_short [Ca(2+)](i) oscillations in ASM: Relationship with persistent airflow obstruction in asthma
title_full [Ca(2+)](i) oscillations in ASM: Relationship with persistent airflow obstruction in asthma
title_fullStr [Ca(2+)](i) oscillations in ASM: Relationship with persistent airflow obstruction in asthma
title_full_unstemmed [Ca(2+)](i) oscillations in ASM: Relationship with persistent airflow obstruction in asthma
title_sort [ca(2+)](i) oscillations in asm: relationship with persistent airflow obstruction in asthma
publisher BlackWell Publishing Ltd
publishDate 2014
url https://ncbi.nlm.nih.gov/pmc/articles/PMC4190647/
https://ncbi.nlm.nih.gov/pubmed/24850215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/resp.12318
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