Novel Type of Prodrug Activation through a Long-Range O,N-Acyl Transfer: A Case of Water-Soluble CREB Inhibitor

[Image: see text] CREB (cAMP response element binding protein) has been shown to play an important role in tumor initiation, progression, and metastasis. We discovered that naphthol AS-E, a cell-permeable CREB inhibitor, presented antiproliferative activity in a broad panel of cancer cell lines in v...

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Detalhes bibliográficos
Main Authors: Li, Bingbing X., Xie, Fuchun, Fan, Qiuhua, Barnhart, Kerry M., Moore, Curtis E., Rheingold, Arnold L., Xiao, Xiangshu
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190631/
https://ncbi.nlm.nih.gov/pubmed/25313320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500330n
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