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Identification, Synthesis and Evaluation of Substituted Benzofurazans as Inhibitors of CREB-mediated Gene Transcription
Cyclic-AMP response-element binding protein (CREB) is a stimulus-activated transcription factor. Its transcription activity requires its binding with CREB-binding protein (CBP) after CREB is phosphorylated at Ser133. The domains involved for CREB-CBP interaction are kinase-inducible domain (KID) fro...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3783659/ https://ncbi.nlm.nih.gov/pubmed/23953193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.07.053 |
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