Resistance to N-peptide fusion inhibitors correlates with thermodynamic stability of the gp41 six-helix bundle but not HIV entry kinetics

BACKGROUND: The HIV-1 envelope glycoprotein (Env) undergoes conformational changes that mediate fusion between virus and host cell membranes. These changes involve transient exposure of two heptad-repeat domains (HR1 and HR2) in the gp41 subunit and their subsequent self-assembly into a six-helix bu...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: De Feo, Christopher J, Wang, Wei, Hsieh, Meng-Lun, Zhuang, Min, Vassell, Russell, Weiss, Carol D
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190581/
https://ncbi.nlm.nih.gov/pubmed/25274545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0086-8
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk