Resistance to N-peptide fusion inhibitors correlates with thermodynamic stability of the gp41 six-helix bundle but not HIV entry kinetics

BACKGROUND: The HIV-1 envelope glycoprotein (Env) undergoes conformational changes that mediate fusion between virus and host cell membranes. These changes involve transient exposure of two heptad-repeat domains (HR1 and HR2) in the gp41 subunit and their subsequent self-assembly into a six-helix bu...

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Bibliographic Details
Main Authors: De Feo, Christopher J, Wang, Wei, Hsieh, Meng-Lun, Zhuang, Min, Vassell, Russell, Weiss, Carol D
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190581/
https://ncbi.nlm.nih.gov/pubmed/25274545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0086-8
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