Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury

BACKGROUND: Optic nerve damage initiates a series of early atrophic events in retinal ganglion cells (RGCs) that precede the BAX-dependent committed step of the intrinsic apoptotic program. Nuclear atrophy, including global histone deacetylation, heterochromatin formation, shrinkage and collapse of...

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Bibliografiska uppgifter
Huvudupphovsmän: Schmitt, Heather M, Pelzel, Heather R, Schlamp, Cassandra L, Nickells, Robert W
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190472/
https://ncbi.nlm.nih.gov/pubmed/25261965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-39
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