Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials

BACKGROUND: Alirocumab is a fully human monoclonal antibody to proprotein convertase subtilisin kexin type 9 (PCSK9) under investigation for treatment of hypercholesterolemia and reduction of cardiovascular events. METHODS/DESIGN: The COMBO studies, part of the Phase 3 ODYSSEY clinical trial program...

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Detalhes bibliográficos
Main Authors: Colhoun, Helen M, Robinson, Jennifer G, Farnier, Michel, Cariou, Bertrand, Blom, Dirk, Kereiakes, Dean J, Lorenzato, Christelle, Pordy, Robert, Chaudhari, Umesh
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190302/
https://ncbi.nlm.nih.gov/pubmed/25240705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2261-14-121
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