TRIM28 regulates RNA polymerase II promoter proximal pausing and pause release

Promoter proximal pausing of RNA polymerase II (Pol II) is a major checkpoint in transcription. An unbiased search for novel human proteins that could regulate paused Pol II at the HSPA1B gene identified TRIM28. In vitro analyses indicated HSF1-dependent attenuation of Pol II pausing upon TRIM28 dep...

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Main Authors: Bunch, Heeyoun, Zheng, Xiaofeng, Burkholder, Adam, Dillon, Simon T., Motola, Shmulik, Birrane, Gabriel, Ebmeier, Christopher C., Levine, Stuart, Fargo, David, Hu, Guang, Taatjes, Dylan J., Calderwood, Stuart K.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189995/
https://ncbi.nlm.nih.gov/pubmed/25173174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2878
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