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The therapeutic potential of chemical chaperones in protein folding diseases
Several neurodegenerative diseases are caused by defects in protein folding, including Alzheimer, Parkinson, Huntington, and prion diseases. Once a disease-specific protein misfolds, it can then form toxic aggregates which accumulate in the brain, leading to neuronal dysfunction, cell death, and cli...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Landes Bioscience
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4189890/ https://ncbi.nlm.nih.gov/pubmed/24818993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.28938 |
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