Leukemogenic Ptpn11 Allele Causes Defective Erythropoiesis in Mice

Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by PTPN11, regulates signaling networks and cell fate in many tissues. Expression of oncogenic PTPN11 in the hematopoietic compartment causes myeloproliferative neoplasm (MPN) in humans and mice. However, the stage-specific effect(...

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Detaylı Bibliyografya
Asıl Yazarlar: Usenko, Tatiana, Chan, Gordon, Torlakovic, Emina, Klingmüller, Ursula, Neel, Benjamin G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188809/
https://ncbi.nlm.nih.gov/pubmed/25289670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109682
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