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Leukemogenic Ptpn11 Allele Causes Defective Erythropoiesis in Mice
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by PTPN11, regulates signaling networks and cell fate in many tissues. Expression of oncogenic PTPN11 in the hematopoietic compartment causes myeloproliferative neoplasm (MPN) in humans and mice. However, the stage-specific effect(...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4188809/ https://ncbi.nlm.nih.gov/pubmed/25289670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109682 |
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