Mitochondrial Abnormality Associates with Type-Specific Neuronal Loss and Cell Morphology Changes in the Pedunculopontine Nucleus in Parkinson Disease

Cholinergic neuronal loss in the pedunculopontine nucleus (PPN) associates with abnormal functions, including certain motor and nonmotor symptoms. This realization has led to low-frequency stimulation of the PPN for treating patients with Parkinson disease (PD) who are refractory to other treatment...

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Main Authors: Pienaar, Ilse S., Elson, Joanna L., Racca, Claudia, Nelson, Glyn, Turnbull, Douglass M., Morris, Christopher M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2013
Teme:
Regular Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188170/
https://ncbi.nlm.nih.gov/pubmed/24099985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.09.002
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