Purification and X-ray crystallographic analysis of 7-keto-8-aminopelargonic acid (KAPA) synthase from Mycobacterium smegmatis

7-Keto-8-aminopelargonic acid synthase (KAPA synthase; BioF) is an essential enzyme for mycobacterial growth that catalyses the first committed step in the biotin-synthesis pathway. It is a pyridoxal 5′-phosphate (PLP)-dependent enzyme and is a potential drug target. Here, the cloning, expression, p...

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Autori principali: Fan, Shanghua, Li, Defeng, Fleming, Joy, Hong, Yuan, Chen, Tao, Zhou, Lin, Bi, Lijun, Wang, Dacheng, Zhang, Xianen, Chen, Guanjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2014
Soggetti:
Crystallization Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188082/
https://ncbi.nlm.nih.gov/pubmed/25286942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14018317
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