UDP-N-Acetylmuramic Acid l-Alanine Ligase (MurC) Inhibition in a tolC Mutant Escherichia coli Strain Leads to Cell Death

The Mur ligases play an essential role in the biosynthesis of bacterial peptidoglycan and hence are attractive antibacterial targets. A screen of the AstraZeneca compound library led to the identification of compound A, a pyrazolopyrimidine, as a potent inhibitor of Escherichia coli and Pseudomonas...

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Autors principals: Humnabadkar, Vaishali, Prabhakar, K. R., Narayan, Ashwini, Sharma, Sreevalli, Guptha, Supreeth, Manjrekar, Praveena, Chinnapattu, Murugan, Ramachandran, Vasanthi, Hameed, Shahul P., Ravishankar, Sudha, Chatterji, Monalisa
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187968/
https://ncbi.nlm.nih.gov/pubmed/25114134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02890-14
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