An Upstream Truncation of the furA-katG Operon Confers High-Level Isoniazid Resistance in a Mycobacterium tuberculosis Clinical Isolate with No Known Resistance-Associated Mutations

Although the major causes of isoniazid (INH) resistance in Mycobacterium tuberculosis are confined to structural mutations in katG and promoter mutations in the mabA-inhA operon, a significant proportion of INH-resistant strains have unknown resistance mechanisms. Recently, we identified a high-leve...

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Bibliographic Details
Main Authors: Siu, Gilman Kit Hang, Yam, Wing Cheong, Zhang, Ying, Kao, Richard Y. T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187958/
https://ncbi.nlm.nih.gov/pubmed/25092698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03277-14
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