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Avibactam and Class C β-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance

Avibactam is a novel non-β-lactam β-lactamase inhibitor that inhibits a wide range of β-lactamases. These include class A, class C, and some class D enzymes, which erode the activity of β-lactam drugs in multidrug-resistant pathogens like Pseudomonas aeruginosa and Enterobacteriaceae spp. Avibactam...

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Bibliografiske detaljer
Main Authors: Lahiri, S. D., Johnstone, M. R., Ross, P. L., McLaughlin, R. E., Olivier, N. B., Alm, R. A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187909/
https://ncbi.nlm.nih.gov/pubmed/25022578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03057-14
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