Masking of β(1-3)-Glucan in the Cell Wall of Candida albicans from Detection by Innate Immune Cells Depends on Phosphatidylserine

The virulence of Candida albicans in a mouse model of invasive candidiasis is dependent on the phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE). Disruption of the PS synthase gene CHO1 (i.e., cho1Δ/Δ) eliminates PS and blocks the de novo pathway for PE biosynthesis. In additio...

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Autors principals: Davis, Sarah E., Hopke, Alex, Minkin, Steven C., Montedonico, Anthony E., Wheeler, Robert T., Reynolds, Todd B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Fungal and Parasitic Infections
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187869/
https://ncbi.nlm.nih.gov/pubmed/25114110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01612-14
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