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Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor Cells

Cyclin-dependent kinase 7 (CDK7) activates cell cycle CDKs and is a member of the general transcription factor TFIIH. Although there is substantial evidence for an active role of CDK7 in mRNA synthesis and associated processes, the degree of its influence on global and gene-specific transcription in...

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Bibliografiske detaljer
Main Authors: Kelso, Timothy W. R., Baumgart, Karen, Eickhoff, Jan, Albert, Thomas, Antrecht, Claudia, Lemcke, Sarah, Klebl, Bert, Meisterernst, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187722/
https://ncbi.nlm.nih.gov/pubmed/25047832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00595-14
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