Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.

A detailed structure-function analysis of human interleukin 5 (hIL5) has been performed. The hIL5 receptor is composed of two different polypeptide chains, the alpha and beta subunits. The alpha subunit alone is sufficient for ligand binding, but association with the beta subunit leads to a 2- to 3-...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Tavernier, J, Tuypens, T, Verhee, A, Plaetinck, G, Devos, R, Van der Heyden, J, Guisez, Y, Oefner, C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41875/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7761472/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.11.5194
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