Nuclear Localization of α1A‐Adrenergic Receptors Is Required for Signaling in Cardiac Myocytes: An “Inside‐Out” α1‐AR Signaling Pathway

BACKGROUND: Recent studies indicate that α1‐adrenergic receptors (α1‐ARs) are cardioprotective by preventing cardiac myocyte death and augmenting contractility in heart failure. Although G‐protein‐coupled receptors are assumed to localize to and signal at the plasma membrane, we previously demonstra...

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Autors principals: Wu, Steven C., Dahl, Erika F., Wright, Casey D., Cypher, Andrew L., Healy, Chastity L., O'Connell, Timothy D.
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2014
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187477/
https://ncbi.nlm.nih.gov/pubmed/24772522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000145
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