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Association of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line lapatinib plus paclitaxel or paclitaxel alone
INTRODUCTION: Phosphatidylinositol 3-kinase (PI3K) pathway deregulation (that is PIK3CA mutations and/or phosphatase and tensin homolog (PTEN) loss) has been shown to enhance breast cancer cell survival and confer resistance to chemotherapeutic agents. We studied the prognostic and predictive value...
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Main Authors: | , , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
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BioMed Central
2014
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Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4187249/ https://ncbi.nlm.nih.gov/pubmed/25056500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0405-y |
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