Loss of Phosphatase and Tensin Homolog or Phosphoinositol-3 Kinase Activation and Response to Trastuzumab or Lapatinib in Human Epidermal Growth Factor Receptor 2–Overexpressing Locally Advanced Breast Cancers

PURPOSE: Phosphatase and tensin homolog (PTEN) loss or activating mutations of phosphoinositol-3 (PI3) kinase (PIK3CA) may be associated with trastuzumab resistance. Trastuzumab, the humanized human epidermal growth factor receptor 2 (HER2) monoclonal antibody, and lapatinib, an epidermal growth fac...

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Hlavní autoři: Dave, Bhuvanesh, Migliaccio, Ilenia, Gutierrez, M. Carolina, Wu, Meng-Fen, Chamness, Gary C., Wong, Helen, Narasanna, Archana, Chakrabarty, Anindita, Hilsenbeck, Susan G., Huang, Jian, Rimawi, Mothaffar, Schiff, Rachel, Arteaga, Carlos, Osborne, C. Kent, Chang, Jenny C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2011
Témata:
Original Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058274/
https://ncbi.nlm.nih.gov/pubmed/21135276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.27.7814
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