α-Klotho protects against oxidative damage in pulmonary epithelia

α-Klotho exerts pleiotropic biological actions. Heterozygous α-Klotho haplo-insufficient mice (kl/+) appear normal at baseline except for age-related changes in the lung, suggesting heightened pulmonary susceptibility to α-Klotho deficiency. We used in vivo and in vitro models to test whether α-Klot...

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Detalhes bibliográficos
Main Authors: Ravikumar, Priya, Ye, Jianfeng, Zhang, Jianning, Pinch, Sydney N., Hu, Ming Chang, Kuro-o, Makoto, Hsia, Connie C. W., Moe, Orson W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187038/
https://ncbi.nlm.nih.gov/pubmed/25063799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00306.2013
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