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Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in atopic dermatitis
We review here how diverse inherited and acquired abnormalities in epidermal structural and enzymatic proteins converge to produce defective permeability barrier function and antimicrobial defense in AD. Although best known are mutations in filaggrin (FLG), mutations in other member of the fused S-1...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4186911/ https://ncbi.nlm.nih.gov/pubmed/25131691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.05.048 |
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