The Apolipoprotein-AI Mimetic Peptide L4F at a Modest Dose Does Not Attenuate Weight Gain, Inflammation, or Atherosclerosis in LDLR-Null Mice

OBJECTIVE: High density lipoprotein (HDL) cholesterol levels are inversely related to cardiovascular disease risk and associated with a reduced risk of type 2 diabetes. Apolipoprotein A-I (apoA-I; major HDL protein) mimetics have been reported to reduce atherosclerosis and decrease adiposity. This s...

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Main Authors: Averill, Michelle M., Kim, Eung Ju, Goodspeed, Leela, Wang, Shari, Subramanian, Savitha, Den Hartigh, Laura J., Tang, Chongren, Ding, Yilei, Reardon, Catherine A., Getz, Godfrey S., Chait, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186861/
https://ncbi.nlm.nih.gov/pubmed/25286043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109252
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