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Structural and Energetic Effects of A(2A) Adenosine Receptor Mutations on Agonist and Antagonist Binding

To predict structural and energetic effects of point mutations on ligand binding is of considerable interest in biochemistry and pharmacology. This is not only useful in connection with site-directed mutagenesis experiments, but could also allow interpretation and prediction of individual responses...

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Hlavní autoři: Keränen, Henrik, Gutiérrez-de-Terán, Hugo, Åqvist, Johan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186821/
https://ncbi.nlm.nih.gov/pubmed/25285959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108492
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