Drug Resistance Is Conferred on the Model Yeast Saccharomyces cerevisiae by Expression of Full-Length Melanoma-Associated Human ATP-Binding Cassette Transporter ABCB5

[Image: see text] ABCB5, an ATP-binding cassette (ABC) transporter, is highly expressed in melanoma cells, and may contribute to the extreme resistance of melanomas to chemotherapy by efflux of anti-cancer drugs. Our goal was to determine whether we could functionally express human ABCB5 in the mode...

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Detalhes bibliográficos
Main Authors: Keniya, Mikhail V., Holmes, Ann R., Niimi, Masakazu, Lamping, Erwin, Gillet, Jean-Pierre, Gottesman, Michael M., Cannon, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186680/
https://ncbi.nlm.nih.gov/pubmed/25115303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500230b
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