Donor CD4(+) Foxp3(+) regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice

Posttransplantation cyclophosphamide (PTCy) is an effective prophylaxis against graft-versus-host disease (GVHD). However, it is unknown whether PTCy works singularly by eliminating alloreactive T cells via DNA alkylation or also by restoring the conventional (Tcon)/regulatory (Treg) T-cell balance....

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Main Authors: Ganguly, Sudipto, Ross, Duncan B., Panoskaltsis-Mortari, Angela, Kanakry, Christopher G., Blazar, Bruce R., Levy, Robert B., Luznik, Leo
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2014
Assuntos:
Transplantation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186542/
https://ncbi.nlm.nih.gov/pubmed/25139358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-525873
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