Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent

In two recent publications, we demonstrated that after allogeneic stimulation, regulatory T cells (T(regs)) increase expression of aldehyde dehydrogenase (ALDH), the major in vivo mechanism of cyclophosphamide detoxification, thereby becoming cyclophosphamide resistant. Differential ALDH expression...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Kanakry, Christopher G, Ganguly, Sudipto, Luznik, Leo
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404790/
https://ncbi.nlm.nih.gov/pubmed/25949893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.974393
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