Isobenzofuranone derivatives exhibit antileishmanial effect by inhibiting type II DNA topoisomerase and inducing host response

Leishmania, a protozoan parasite, causes a wide range of human diseases ranging from the localized self-healing cutaneous lesions to fatal visceral leishmaniasis. Toxicity of traditional first line drugs and emergence of drug-resistant strains have worsened the situation. DNA topoisomerase II in kin...

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Bibliografiske detaljer
Main Authors: Mishra, Amartya, Vinayagam, Jayaraman, Saha, Sourav, Chowdhury, Sayan, Roychowdhury, Somenath, Jaisankar, Parasuraman, Majumder, Hemanta K
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2014
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186449/
https://ncbi.nlm.nih.gov/pubmed/25505614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.70
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