O4.03 GLIOBLASTOMA STIMULATED ANGIOGENESIS IS MEDIATED BY MMP-3 ACTIVATED MMP-1 VIA BRAIN ENDOTHELIAL CELL ASSOCIATED PROTEASE ACTIVATED RECEPTOR 1 (PAR1) AND IS ENHANCED UNDER HYPOXIC CONDITIONS

Glioblastoma Multiforme is a highly aggressive brain tumour known for its heterogeneity and its vascularity. Published reports using in vivo and in vitro glioma models reveal that Matrix metalloproteinase-1 (MMP-1) over-expression induces angiogenesis. In other studies the involvement of the Proteas...

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Main Authors: Briggs, S., Stephenson, K., Holliday, J., Peckham, R., Arthur, D., Papanikolaou, M., Butt, A., Pickford, A., Pilkington, G., Fillmore, H.L.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2014
主題:
Oral Presentations
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185594/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou174.24
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