Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis

Global change in protein turnover (protein degradome) constitutes a central part of cellular responses to intrinsic or extrinsic stimuli. However, profiling protein degradome remains technically challenging. Recently, inhibition of the proteasome, e.g., by using bortezomib (BTZ), has emerged as a ma...

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Hlavní autoři: Yu, Tao, Tao, Yonghui, Yang, Meiqiang, Chen, Peng, Gao, Xiaobo, Zhang, Yanbo, Zhang, Tao, Chen, Zi, Hou, Jian, Zhang, Yan, Ruan, Kangcheng, Wang, Hongyan, Hu, Ronggui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185348/
https://ncbi.nlm.nih.gov/pubmed/25223703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.122
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