Ganglioside GM1 binds to the Trk protein and regulates receptor function.
Several lines of evidence have suggested that ganglioside GM1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF), but its precise mechanism is yet to be elucidated. We report here that GM1 directly and tightly associates with Trk, the high-affinity tyrosine kinase-typ...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1995
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41853/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7539142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.11.5087 |
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