Resident alveolar macrophages suppress while recruited monocytes promote allergic lung inflammation in murine models of asthma

The role and origin of alveolar macrophages (AMs) in asthma are incompletely defined. We sought to clarify these issues in the context of acute allergic lung inflammation utilizing house dust mite and ovalbumin murine models. Use of liposomal clodronate to deplete resident AMs (rAMs) resulted in inc...

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Main Authors: Zasłona, Zbigniew, Przybranowski, Sally, Wilke, Carol, van Rooijen, Nico, Teitz-Tennenbaum, Seagal, Osterholzer, John J., Wilkinson, John E., Moore, Bethany B., Peters-Golden, Marc
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185233/
https://ncbi.nlm.nih.gov/pubmed/25225663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400580
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