Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy

PURPOSE: Immunomodulatory drugs differ in mechanism-of-action from directly cytotoxic cancer therapies. Identifying factors predicting clinical response could guide patient selection and therapeutic optimization. EXPERIMENTAL DESIGN: Patients (N=41) with melanoma, non-small cell lung carcinoma (NSCL...

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Huvudupphovsmän: Taube, Janis M., Klein, Alison, Brahmer, Julie R., Xu, Haiying, Pan, Xiaoyu, Kim, Jung H., Chen, Lieping, Pardoll, Drew M., Topalian, Suzanne L., Anders, Robert A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185001/
https://ncbi.nlm.nih.gov/pubmed/24714771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3271
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