In Vivo Time-Related Evaluation of a Therapeutic Neutralization Monoclonal Antibody against Lethal Enterovirus 71 Infection in a Mouse Model

Enterovirus 71 (EV71) is a neurotropic virus capable of inducing severe neurological symptoms and death. No direct targeting antivirals are useful in the treatment of severe EV71 infection. Because of low toxicity and good specificity, monoclonal antibodies (MAb) are a potential candidate for the tr...

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Main Authors: Li, Zhiqun, Xu, Longfa, He, Delei, Yang, Lisheng, Liu, Che, Chen, Yixin, Shih, James Wai Kuo, Zhang, Jun, Zhao, Qinjian, Cheng, Tong, Xia, Ningshao
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184856/
https://ncbi.nlm.nih.gov/pubmed/25279734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109391
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