LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity

OBJECTIVE: Mutations in leucine-rich repeat kinase 2 (LRRK2) pose a significant genetic risk in familial and sporadic Parkinson's disease (PD). R1441 mutation (R1441G/C) in its GTPase domain is found in familial PD. How LRRK2 interacts with synaptic proteins, and its role in dopamine (DA) homeo...

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Main Authors: Liu, Hui-Fang, Lu, Song, Ho, Philip Wing-Lok, Tse, Ho-Man, Pang, Shirley Yin-Yu, Kung, Michelle Hiu-Wai, Ho, Jessica Wing-Man, Ramsden, David B, Zhou, Zhong-Jun, Ho, Shu-Leong
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184549/
https://ncbi.nlm.nih.gov/pubmed/25356398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.45
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