Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

FGF1 is an autocrine/paracrine regulator whose binding to heparan sulfate proteoglycans effectively precludes its circulation (1,2). Though known as a mitogenic factor, FGF1 knockout mice develop insulin resistance when stressed by a high fat diet, suggesting a potential role in nutrient homeostasis...

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Main Authors: Suh, Jae Myoung, Jonker, Johan W., Ahmadian, Maryam, Goetz, Regina, Lackey, Denise, Osborn, Olivia, Huang, Zifeng, Liu, Weilin, Yoshihara, Eiji, van Dijk, Theo, Havinga, Rick, Fan, Weiwei, Yin, Yun-Qiang, Yu, Ruth T., Liddle, Christopher, Atkins, Annette R., Olefsky, Jerrold M., Mohammadi, Moosa, Downes, Michael, Evans, Ronald M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184286/
https://ncbi.nlm.nih.gov/pubmed/25043058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13540
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