Krebs Cycle Metabolite Profiling for Identification and Stratification of Pheochromocytomas/Paragangliomas due to Succinate Dehydrogenase Deficiency

CONTEXT: Mutations of succinate dehydrogenase A/B/C/D genes (SDHx) increase susceptibility to development of pheochromocytomas and paragangliomas (PPGLs), with particularly high rates of malignancy associated with SDHB mutations. OBJECTIVE: We assessed whether altered succinate dehydrogenase product...

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Autori principali: Richter, Susan, Peitzsch, Mirko, Rapizzi, Elena, Lenders, Jacques W., Qin, Nan, de Cubas, Aguirre A., Schiavi, Francesca, Rao, Jyotsna U., Beuschlein, Felix, Quinkler, Marcus, Timmers, Henri J., Opocher, Giuseppe, Mannelli, Massimo, Pacak, Karel, Robledo, Mercedes, Eisenhofer, Graeme
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2014
Soggetti:
Endocrine Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184070/
https://ncbi.nlm.nih.gov/pubmed/25014000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-2151
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