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Genetic Instability of Influenza pH1N1 Viruses

Here, we report full-length genome sequences of influenza pH1N1 viruses obtained prior to and after propagation in MDCK cells. Paired comparisons of the genomes showed that each strain acquired 1.0 to 18.8 mutations per genome per replication cycle, which corresponds to 0.5 to 5.8 mutations per viru...

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Detalhes bibliográficos
Main Authors: Jalovaara, Petri, Bychkov, Dmitrii, Ahtiainen, Laura, Kallio-Kokko, Hannimari, Valkonen, Miia, Kantele, Anu, Mattila, Pirkko, Almusa, Henrikki, Kallioniemi, Olli, Kainov, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183864/
https://ncbi.nlm.nih.gov/pubmed/25278520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/genomeA.00841-14
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