Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells

Here, we sequenced the genome of the influenza A/Finland/741 M/2014(H1N1) virus and found that the virus accumulated oseltamivir resistance mutation H275Y in its neuraminidase during propagation in cell culture. This indicates that propagation in cell culture modifies virus genomes. The instability...

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Detalles Bibliográficos
Publicado en:Genome Announc
Autores principales: Mishel, Polina, Bychkov, Dmitrii, Kallio-Kokko, Hannimari, Valkonen, Miia, Kantele, Anu, Mattila, Pirkko, Almusa, Henrikki, Jalovaara, Petri, Kainov, Denis
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Viruses
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276832/
https://ncbi.nlm.nih.gov/pubmed/25540354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/genomeA.01349-14
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