Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells

Here, we sequenced the genome of the influenza A/Finland/741 M/2014(H1N1) virus and found that the virus accumulated oseltamivir resistance mutation H275Y in its neuraminidase during propagation in cell culture. This indicates that propagation in cell culture modifies virus genomes. The instability...

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Detalhes bibliográficos
Publicado no:Genome Announc
Main Authors: Mishel, Polina, Bychkov, Dmitrii, Kallio-Kokko, Hannimari, Valkonen, Miia, Kantele, Anu, Mattila, Pirkko, Almusa, Henrikki, Jalovaara, Petri, Kainov, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Viruses
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276832/
https://ncbi.nlm.nih.gov/pubmed/25540354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/genomeA.01349-14
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