Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells

BACKGROUND: Constitutive activation of signal transducer and activator of transcription signalling 3 (STAT3) has been linked with survival, proliferation and angiogenesis in a wide variety of malignancies including hepatocellular carcinoma (HCC). METHODS: We evaluated the effect of lupeol on STAT3 s...

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Bibliografiska uppgifter
Huvudupphovsmän: Siveen, K S, Nguyen, A H, Lee, J H, Li, F, Singh, S S, Kumar, A P, Low, G, Jha, S, Tergaonkar, V, Ahn, K S, Sethi, G
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2014
Ämnen:
Translational Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183851/
https://ncbi.nlm.nih.gov/pubmed/25101566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.422
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