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Mitogen-activated Protein Kinase (MAPK) Hyperactivation and Enhanced NRAS Expression Drive Acquired Vemurafenib Resistance in V600E BRAF Melanoma Cells
Although targeting the V600E activating mutation in the BRAF gene, the most common genetic abnormality in melanoma, has shown clinical efficacy in melanoma patients, response is, invariably, short lived. To better understand mechanisms underlying this acquisition of resistance to BRAF-targeted thera...
সংরক্ষণ করুন:
| প্রধান লেখক: | , , , , , , , |
|---|---|
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
American Society for Biochemistry and Molecular Biology
2014
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183808/ https://ncbi.nlm.nih.gov/pubmed/25063807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.532432 |
| ট্যাগগুলো: |
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