Mitogen-activated Protein Kinase (MAPK) Hyperactivation and Enhanced NRAS Expression Drive Acquired Vemurafenib Resistance in V600E BRAF Melanoma Cells

Although targeting the V600E activating mutation in the BRAF gene, the most common genetic abnormality in melanoma, has shown clinical efficacy in melanoma patients, response is, invariably, short lived. To better understand mechanisms underlying this acquisition of resistance to BRAF-targeted thera...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Lidsky, Michael, Antoun, Gamil, Speicher, Paul, Adams, Bartley, Turley, Ryan, Augustine, Christi, Tyler, Douglas, Ali-Osman, Francis
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2014
الموضوعات:
Molecular Bases of Disease
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183808/
https://ncbi.nlm.nih.gov/pubmed/25063807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.532432
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