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Aminoluciferins Extend Firefly Luciferase Bioluminescence into the Near-Infrared and Can Be Preferred Substrates over d-Luciferin

[Image: see text] Firefly luciferase adenylates and oxidizes d-luciferin to chemically generate visible light and is widely used for biological assays and imaging. Here we show that both luciferase and luciferin can be reengineered to extend the scope of this light-emitting reaction. d-Luciferin can...

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Detalhes bibliográficos
Main Authors: Mofford, David M., Reddy, Gadarla Randheer, Miller, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183640/
https://ncbi.nlm.nih.gov/pubmed/25208457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja505795s
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