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Asymmetric Mannich Synthesis of α-Amino Esters by Anion-Binding Catalysis
[Image: see text] We report a scalable, one-pot Mannich route to enantioenriched α-amino esters by direct reaction of α-chloroglycine ester as a practical imino ester surrogate. The reaction is promoted by a chiral aminothiourea, which is proposed to operate cooperatively by generating an iminium io...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Chemical
Society
2014
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183616/ https://ncbi.nlm.nih.gov/pubmed/25178040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5075163 |
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