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Evidence of Conformational Selection Driving the Formation of Ligand Binding Sites in Protein-Protein Interfaces

Many protein-protein interactions (PPIs) are compelling targets for drug discovery, and in a number of cases can be disrupted by small molecules. The main goal of this study is to examine the mechanism of binding site formation in the interface region of proteins that are PPI targets by comparing li...

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Detalhes bibliográficos
Main Authors: Bohnuud, Tanggis, Kozakov, Dima, Vajda, Sandor
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183424/
https://ncbi.nlm.nih.gov/pubmed/25275445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003872
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