Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade

Metastatic spread is the leading cause of cancer mortality. Breast cancer (BCa) metastatic recurrence can happen years after removal of the primary tumor. Here we show that Ubc13, an E2 enzyme that catalyzes K63-linked protein polyubiquitination, is largely dispensable for primary mammary tumor grow...

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Detalhes bibliográficos
Main Authors: Wu, Xuefeng, Zhang, Weizhou, Font-Burgada, Joan, Palmer, Trenis, Hamil, Alexander S., Biswas, Subhra K., Poidinger, Michael, Borcherding, Nicholas, Xie, Qing, Ellies, Lesley G., Lytle, Nikki K., Wu, Li-Wha, Fox, Raymond G., Yang, Jing, Dowdy, Steven F., Reya, Tannishtha, Karin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183333/
https://ncbi.nlm.nih.gov/pubmed/25189770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414358111
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