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Retroviral oncoprotein Tax deregulates NF-κB by activating Tak1 and mediating the physical association of Tak1–IKK
The Tax oncoprotein of human T-cell leukaemia virus type I (HTLV-I) persistently activates nuclear factor-κB (NF-κB), which is required for HTLV-I-mediated T-cell transformation. Tax activates NF-κB by stimulating the activity of IκB kinase (IKK), but the underlying mechanism remains elusive. Here,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1866198/ https://ncbi.nlm.nih.gov/pubmed/17363973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400931 |
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