PreImplantation factor promotes neuroprotection by targeting microRNA let-7

Dysfunction and loss of neurons are the major characteristics of CNS disorders that include stroke, multiple sclerosis, and Alzheimer’s disease. Activation of the Toll-like receptor 7 by extracellular microRNA let-7, a highly expressed microRNA in the CNS, induces neuronal cell death. Let-7 released...

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Bibliographic Details
Main Authors: Mueller, Martin, Zhou, Jichun, Yang, Lihua, Gao, Yuan, Wu, Fuju, Schoeberlein, Andreina, Surbek, Daniel, Barnea, Eytan R., Paidas, Michael, Huang, Yingqun
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183321/
https://ncbi.nlm.nih.gov/pubmed/25205808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411674111
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