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Calcium sensitive ring-like oligomers formed by synaptotagmin
The synaptic vesicle protein synaptotagmin-1 (SYT) is required to couple calcium influx to the membrane fusion machinery. However, the structural mechanism underlying this process is unclear. Here we report an unexpected circular arrangement (ring) of SYT’s cytosolic domain (C2AB) formed on lipid mo...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183308/ https://ncbi.nlm.nih.gov/pubmed/25201968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415849111 |
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